Peanut allergy can be treated early with a vaccine

By | August 6, 2018

A new study shows how the vaccine can alter the immune response of peanuts in mice, thus stopping the detection of the allergic reaction. These results may soon be transferable to humans.
Peanut with syringe
Researchers will soon be able to develop an effective vaccine against peanut allergy in humans.
The Centers for Disease Control and activated xtnd Prevention (CDC) believes that food allergies “are a growing concern for food safety and public health.”

It is estimated that between 4 and 6 percent of all children in the United States suffer from food allergies, although other reports reveal that the proportion is much higher.

Among all types of food allergies, peanut beans are the most common.

Food allergies do not yet have a cure, allergic reactions can be fatal. In fact, the only way to prevent “allergies” is to get away from allergens.

However, a new study offers hope for people who are allergic to peanuts, where the vaccine, produced in two decades, has been shown to be successful in mice.

This research, now published in the Journal of Clinical Allergy and Immunology, was conducted by scientists at the University of Michigan in Ann Arbor. And its leader, Jessica O’Connick, researcher at the Center for Food Allergy at the University.

Stop allergy to peanuts in rats
O’Connick and his team explain that food allergies are caused by a defective immune response, in which the body secretes antibodies called immunoglobulin E (IgE).

This is the result of a heterogeneous immune response of immune cells called T helper 2 (Th2). In the new research, scientists hypothesized that the redirection of these Th2 cells can help regulate the immune response to allergies.

To test this hypothesis, O’Konek and his colleagues sensitized mice to peanut proteins so that their immune system produced IgE antibodies and that their Th2 cells behaved in the same way as allergic reactions.

When the flasks are exposed to peanuts, rodents are affected by the same symptoms of allergies, such as itchy skin and obstruction of breathing, as humans.

The researchers then administered rodent doses of the nasal vaccine monthly for 3 months and measured their allergic response two weeks after the final dose.
“Possible treatment of allergies in humans”
Once researchers discover if they can extend the benefits of the vaccine and fully understand the mechanisms by which the vaccine suppresses sensitivity, the results can be used to start a clinical trial in humans.

“Currently, the FDA’s only approach to food allergies is to avoid food or suppress allergic reactions after they have already started,” O’Connick said.

“Our goal is to use immunotherapy to change the response of the immune system through the development of a therapeutic vaccine for food allergies.”

The researcher in the study, Dr. James Baker, director of the Mary H. program “Food allergies have spread, but we still know very little about it because there has not been much research in this area,” he said. Allergy Center at the University of Michigan.

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